Koh Shingu Selected Research

Intravenous Anesthetics

8/2017	Mitigation of inflammation using the intravenous anesthetic dexmedetomidine in the mouse air pouch model.
7/2015	Intravenous anesthetic propofol suppresses prostaglandin E2 and cysteinyl leukotriene production and reduces edema formation in arachidonic acid-induced ear inflammation.
8/2011	Possible link between cyclooxygenase-inhibiting and antitumor properties of propofol.
10/2010	Promotion of interferon-gamma production by natural killer cells via suppression of murine peritoneal macrophage prostaglandin E₂ production using intravenous anesthetic propofol.
1/2009	Propofol suppresses prostaglandin E(2) production in human peripheral monocytes.

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Koh Shingu Research Topics

Disease

7	Hypoxia (Hypoxemia) 09/2010 - 11/2004
6	Pain (Aches) 01/2019 - 10/2003
5	Neoplasms (Cancer) 01/2019 - 01/2005
4	Inflammation (Inflammations) 08/2017 - 01/2009
4	Ischemia 12/2005 - 05/2003
3	Infections 01/2013 - 01/2009
3	Tachycardia (Tachyarrhythmias) 01/2010 - 02/2005
2	Postoperative Pain 05/2017 - 11/2003
2	Pneumothorax 10/2014 - 08/2006
2	Heart Failure 10/2014 - 02/2005
2	Hemorrhage 04/2013 - 10/2007
2	Wounds and Injuries (Trauma) 10/2010 - 06/2003
2	Malignant Hyperthermia 01/2010 - 02/2003
2	Brain Ischemia (Cerebral Ischemia) 07/2009 - 06/2003
2	Heart Arrest (Cardiac Arrest) 07/2009 - 10/2007
2	Pathologic Constriction (Stenosis) 10/2008 - 08/2004
2	Infarction (Infarctions) 12/2005 - 03/2004
2	Airway Obstruction (Choking) 10/2004 - 08/2004
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Cancer Pain 01/2019
1	Gallstones (Gallstone) 05/2017
1	Respiratory Insufficiency (Respiratory Failure) 05/2017
1	Myotonic Dystrophy (Dystrophia Myotonica) 05/2017
1	Necrosis 10/2016
1	Acute Kidney Injury (Acute Renal Failure) 10/2016
1	Deglutition Disorders (Dysphagia) 02/2016
1	Stiff-Person Syndrome (Stiff Man Syndrome) 02/2016
1	Nervous System Diseases (Neurological Disorders) 02/2016
1	Progressive Bulbar Palsy (Fazio Londe Syndrome) 02/2016
1	Muscle Rigidity 02/2016
1	Otitis 07/2015
1	Edema (Dropsy) 07/2015
1	Dyskinesias (Dyskinesia) 04/2015
1	Myoclonus (Nocturnal Myoclonus) 04/2015
1	Subcutaneous Emphysema 10/2014
1	Barotrauma 10/2014
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 10/2014
1	Mediastinal Emphysema (Pneumomediastinum) 10/2014
1	Contact Dermatitis (Eczema, Contact) 10/2013
1	Critical Illness (Critically Ill) 10/2013
1	Rectal Neoplasms (Rectal Cancer) 04/2013
1	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2013

Drug/Important Bio-Agent (IBA)

12	Propofol (Diprivan)FDA LinkGeneric 05/2017 - 01/2002
6	Anesthetics (Anesthetic Agents)IBA 02/2016 - 02/2003
5	Intravenous AnestheticsIBA 08/2017 - 01/2009
4	ProstaglandinsIBA 08/2011 - 01/2009
4	Sevoflurane (Ultane)FDA LinkGeneric 01/2010 - 01/2002
3	Analgesics (Analgesic Drugs)IBA 01/2019 - 11/2003
3	Dexmedetomidine FDA Link 08/2017 - 01/2005
3	Oxygen (Dioxygen)IBA 05/2008 - 08/2004
3	Isoflurane FDA LinkGeneric 12/2005 - 01/2002
2	Opioid Analgesics (Opioids)IBA 01/2019 - 05/2017
2	Pharmaceutical PreparationsIBA 08/2017 - 01/2009
2	SugammadexIBA 05/2017 - 10/2011
2	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 10/2016 - 04/2015
2	Local AnestheticsIBA 10/2016 - 01/2005
2	Midazolam (Versed)FDA LinkGeneric 04/2015 - 01/2007
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 04/2011 - 03/2009
2	Fentanyl (Sublimaze)FDA LinkGeneric 01/2010 - 11/2003
2	Neuroprotective AgentsIBA 07/2009 - 06/2003
2	Halothane (Fluothane)FDA Link 01/2005 - 01/2002
1	Betamethasone (Celestone)FDA Link 01/2019
1	CarrageenanIBA 08/2017
1	ChemokinesIBA 08/2017
1	Ropivacaine (Naropin)FDA LinkGeneric 05/2017
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 10/2016
1	Lidocaine (Xylocaine)FDA LinkGeneric 10/2016
1	FITC-annexin A5IBA 10/2016
1	Mepivacaine (Carbocaine)FDA LinkGeneric 10/2016
1	Caspase 3 (Caspase-3)IBA 10/2016
1	Caspase 9IBA 10/2016
1	Starch (Cornstarch)IBA 10/2016
1	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 02/2016
1	gamma-Aminobutyric Acid (GABA)IBA 02/2016
1	AntibodiesIBA 02/2016
1	Peroxidase (Myeloperoxidase)IBA 07/2015
1	Arachidonic Acid (Vitamin F)IBA 07/2015
1	Dinoprostone (PGE2)FDA Link 07/2015
1	cysteinyl-leukotrieneIBA 07/2015
1	LeukotrienesIBA 07/2015
1	SteroidsIBA 10/2014
1	RHO(D) antibody (anti-D)IBA 04/2013
1	Rho(D) Immune Globulin (RhoGAM)IBA 04/2013
1	ProcalcitoninIBA 01/2013
1	Interleukin-6 (Interleukin 6)IBA 01/2013

Therapy/Procedure

9	Anesthesia 04/2015 - 01/2002
5	General Anesthesia 05/2017 - 11/2003
5	Spinal Anesthesia 04/2015 - 02/2005
4	Artificial Respiration (Mechanical Ventilation) 10/2014 - 01/2004
3	Cesarean Section (Caesarean Section) 04/2015 - 01/2005
3	Airway Management 02/2010 - 08/2004
3	One-Lung Ventilation 04/2006 - 05/2003
2	Laparoscopic Cholecystectomy 05/2017 - 11/2003
2	Epidural Anesthesia 04/2015 - 08/2005
2	Therapeutics 10/2014 - 01/2013
2	Critical Care (Surgical Intensive Care) 10/2013 - 01/2005
2	Catheters 08/2004 - 10/2003
1	Analgesia 01/2019
1	Spinal Injections 01/2019
1	Repeat Cesarean Section 04/2015